Calcium
and Its Role in Heart Failure
This study
had a lot to do with what we just went over in lecture for the human physiology
course. In the introduction, it talks about the excitation-contraction that
calcium mediates as well as the sarcoplasmic reticulum and action potentials
and how these are affected during heart failure.
There is a
certain protein called sarcoplasmic reticulum calcium ATPase or SERCA for short
that is the protein that is responsible for removing cytosolic calcium and returning
it to the SR during diastole. If something goes wrong with the function of
SERCA, then the balance of calcium in the heart is thrown off and cannot
properly regulate its rhythm with regards to the action potential. There is
also problems with the muscle contractions since calcium is needed to have a
contraction and for there to be a cross bridge between myosin and actin.
The study
found that if SERCA can be reregulated, then the homeostasis that is thrown off
by heart failure can be returned to normal and some of the negative effects of
heart failure also disappeared. The study, however, said that there wasn’t enough
data for the results to be statistically significant and that more data would
be needed before meaningful conclusions could be drawn.
Mora, M. T., Ferrero, J. M.,
Romero, L., & Trenor, B. (2017). Sensitivity analysis revealing the effect
of modulating ionic mechanisms on calcium dynamics in simulated human heart
failure. PLoS ONE, 12(11), e0187739.
http://doi.org/10.1371/journal.pone.0187739
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